A 4-1 away loss for the Istanbul club lessens their chances of proceeding in the Champions League
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Galatasaray lost 4-1 to Arsenal in Wednesdays Champions League match in London.
Danny Welbecks 22nd minute goal put Arsenal ahead before making it 2-0 eight minutes later.
Just before half-time Arsenal made it 3-0 after Alexis Sanchez finished in the box.
In the 52nd minute Welbeck got his hat-trick with a classy finish to make it 4-0.
The visitors were thrown a lifeline when keeper Wojciech Szczesny brought down Burak Yilmaz in the box. Szczesny was sent off in the 60th minute and Burak converted the penalty successfully to make it 4-1.
In the other Group D game, Borussia Dortmund eased past Anderlecht 3-0 in Brussels. Ciro Immobile and Adrian Ramos scored for the Germans.
Wednesday nights results are as follows:
Atletico Madrid 1-0 Juventus Malmo 2-0 Olympiakos Zenit 0-0 Monaco Anderlecht 0-3 Borussia Dortmund Leverkusen 3-1 Benfica Ludogorets 1-2 Real Madrid Basel 1-0 Liverpool