The airstrikes on civilian residential areas killed 27 in Arbin, 17 in Jisrin, 2 in Zamalka, 3 in Sabka, 3 in Misraba, 7 in Hamuriya, 1 in Bayt Sava and another in Madyara neighborhoods, the sources told Anadolu Agency.
Also, eight civilians were killed in Duma, four in Hazzah and another two civilians were killed in Harasta, said the civil defense units, also known as the White Helmets.
The White Helmets were dispatched to the scene for search and rescue as death toll was feared to increase.
The regime forces have been conducting intensified airstrikes on the region since Thursday morning.
Located in the outskirt of capital Damascus, Eastern Ghouta was declared a de-escalation zone in which acts of aggression are forbidden.
The Syrian regime, however, has repeatedly violated the deal and has targeted residential areas in the city killing a total of 524 people and leaving around 2,000 others injured since Dec. 29, 2017.
Home to roughly 400,000 residents, Eastern Ghouta has remained under a crippling regime siege for the last five years.
Syria has been locked in a devastating civil war since March 2011, when the Assad regime cracked down on pro-democracy protests with unexpected ferocity.
While UN officials say hundreds of thousands of people have been killed in the conflict, regime officials say the death toll is closer to 10,000.