Speaking to Anadolu Agency, Simsek said his comments quoted by Russian Sputnik news agency at the World Economic Forum in Davos did not reflect the truth and his remarks were "distorted”.
Earlier, Sputnik quoted Simsek saying, "Turkey can no longer insist on an agreement without Assad."
“I do not have any comment on Assad. That was totally distorted. This was interpretation of an international [news] agency,” Simsek told Anadolu Agency.
“I told this; if there is a [person] responsible for the human tragedy in Syria, that is Assad. I told it was impossible to accept a state where he is in [power]," the deputy prime minister added.
In his remarks, Simsek said the top priority was to end the human tragedy in the conflict-hit country.
Following last month's ceasefire deal, brokered by Turkey and Russia, the Syrian government and opposition negotiators are set for talks on Jan. 23. in the Kazakh capital, Astana.
Syria has been locked in a devastating civil war since early 2011, when the Assad regime cracked down on pro-democracy protests with unexpected ferocity.